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Fragment 176-191

Fragment 176-191

Metabolic Pathway Research

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Fragment 176-191

Fragment 176-191

Metabolic Pathway Research

Fragment 176-191

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Research Use Only

These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.

What is it?

Fragment 176-191, also known as hGH Fragment 176-191 or somatotropin 176-191, is a synthetic 16-amino-acid peptide corresponding to residues 176 through 191 of the C-terminal region of human growth hormone. It isolates a segment of the hGH molecule associated with lipolytic activity in experimental models. Unlike full-length hGH, Fragment 176-191 is studied as a targeted metabolic research compound without the broader GH-receptor and IGF-1 signaling profile of the intact hormone.

Certificate of Analysis

This research peptide is verified for identity, composition consistency, and 99%+ purity through analytical quality-control testing. Certificate of Analysis documentation is available for Fragment 176-191 (10 mg).

Frequently Asked Questions

Does the product come with instructions?

Products from Elite Miami Peptides do not include usage instructions, as they are strictly for in vitro research and prohibited by law for human or animal use. Misuse or unlawful application will result in permanent denial of service.

Each vial contains exactly what’s indicated on the label. For instance, a 10mg vial contains precisely 10mg of lyophilized peptide. Researchers may divide it into smaller research portions—such as four 2.5mg aliquots—but the total content remains the same.

Yes. All peptides are supplied in lyophilized powder form and do not come reconstituted. Any extra materials required for research, such as solvents or diluents, must be obtained separately.

When stored as a dry powder, peptides remain stable for up to 2 years.
Once reconstituted, the solution should be kept refrigerated and is typically stable for up to 2 months under proper storage conditions.

Overview

Fragment 176-191 is a C-terminal human growth hormone peptide fragment studied for its interaction with adipocyte lipid-metabolism pathways. Experimental research examines its influence on lipolysis, fatty-acid oxidation, lipid storage, and beta-3 adrenergic receptor-associated signaling. Because it represents a defined region of the hGH sequence, it is used to investigate metabolic activity separately from the broader growth, receptor-binding, and IGF-1-mediated effects associated with full-length human growth hormone.

Explanation

Fragment 176-191 is a laboratory-made copy of a small section of the human growth hormone molecule. Researchers use it to study how fat cells store and break down lipids and how metabolic pathways are regulated without examining the full range of growth hormone activity. Fragment 176-191 supplied for research is intended exclusively for laboratory and in-vitro investigation and is not approved for human or animal use.

⚠️ Disclaimer: this product is not approved for medical use and is not intended to diagnose, treat, or prevent any disease. All information provided is for educational and research purposes only, and this product must never be used in humans or animals.

History

Scientific interest in the C-terminal region of human growth hormone developed during research conducted in the 1970s and 1980s. Investigators proposed that some of the hormone’s experimentally observed lipolytic activity could be associated with a specific region rather than the entire 191-amino-acid sequence. Fragment 176-191 was subsequently studied as a defined C-terminal peptide for metabolic and adipocyte research. A modified related analog, AOD9604, was later developed separately, while Fragment 176-191 has remained primarily a preclinical laboratory research compound.

Structure

Classification: Synthetic C-terminal human growth hormone peptide fragment Molecular Formula: C₇₈H₁₂₃N₂₃O₂₂S₂ Molecular Weight: 1799.1 g/mol Sequence Length: 16 amino acids Sequence: LRIVQCRSVEGSCGFY Three-Letter Sequence: Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-Tyr Parent Molecule: Human growth hormone, residues 176–191 CAS Number: 66004-57-7 PubChem ID: CID 16131230 Structural Characteristic: C-terminal peptide fragment containing two cysteine residues

Research Findings

Fragment 176-191 has been examined in metabolic, adipocyte, and comparative hormone research models. Studies have investigated its effects on lipolytic activity, fatty-acid oxidation, lipid storage and breakdown, and beta-3 adrenergic receptor expression in adipose-tissue models. Comparative experiments have also explored its lack of conventional growth hormone receptor binding and the absence of the broader IGF-1-mediated response associated with intact hGH. These findings support its use as a targeted laboratory tool for studying lipid metabolism and adipocyte signaling.

Explanation

In simple terms, researchers study Fragment 176-191 to understand how a small section of the growth hormone molecule may influence fat-cell activity. Laboratory experiments examine how it affects fat breakdown, fatty-acid use, lipid storage, and metabolic signaling without reproducing the full signaling profile of human growth hormone. These studies are intended to investigate cellular mechanisms and are not directions for human or veterinary use.

References

Ng, F. M., & Bornstein, J. (1978). Studies of the lipolytic activity associated with fragments of human growth hormone. Heffernan, M. A., Jiang, W. J., Thorburn, A. W., & Ng, F. M. (2001). Effects of a synthetic growth hormone lipolytic domain on lipid metabolism and beta-3 adrenergic receptor expression in experimental models.

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Research Use Only

These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.

Research Use Only

All compounds from Elite Miami Peptides are intended strictly for laboratory research purposes.

They are not for human use, consumption, or therapeutic applications.
Products are supplied exclusively to qualified professionals working in compliance with all applicable laws and regulations.