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These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor widely used in research on NAD⁺ metabolism, adipocyte biology and metabolic disorders. Each capsule contains 50 mg of 5-Amino-1MQ, with 60 capsules per bottle for flexible oral-dosing research protocols.
This compound is supplied at ≥98–99% purity as confirmed by HPLC and/or LC-MS. The Certificate of Analysis documents identity (5-amino-1-methylquinolinium salt), molecular formula (e.g., C₁₀H₁₁N₂⁺ with appropriate counter-ion), potency (50 mg/capsule), water content and impurity profile, ensuring suitability for in-vitro and in-vivo research applications.
Products from Elite Miami Peptides do not include usage instructions, as they are strictly for in vitro research and prohibited by law for human or animal use. Misuse or unlawful application will result in permanent denial of service.
Each vial contains exactly what’s indicated on the label. For instance, a 10mg vial contains precisely 10mg of lyophilized peptide. Researchers may divide it into smaller research portions—such as four 2.5mg aliquots—but the total content remains the same.
Yes. All peptides are supplied in lyophilized powder form and do not come reconstituted. Any extra materials required for research, such as solvents or diluents, must be obtained separately.
When stored as a dry powder, peptides remain stable for up to 2 years.
Once reconstituted, the solution should be kept refrigerated and is typically stable for up to 2 months under proper storage conditions.
5-Amino-1MQ is a selective, substrate-site-targeting NNMT inhibitor with low-micromolar IC₅₀. By blocking NNMT, it reduces formation of 1-methylnicotinamide and can increase intracellular NAD⁺ and S-adenosylmethionine pools, thereby modulating energy metabolism, methyl-donor balance and adipocyte lipogenesis in experimental systems
In everyday language, 5-Amino-1MQ is a lab chemical used to turn down an enzyme (NNMT) that burns through vitamin-B-related molecules inside cells. When this enzyme is inhibited in research models, cells may keep more NAD⁺ available, which lets scientists study how changes in cellular energy and fat-storage pathways affect metabolism. This material is provided strictly for research use, not as a supplement or drug.
⚠️ Disclaimer: this product is not approved for medical use and is not intended to diagnose, treat, or prevent any disease. All information provided is for educational and research purposes only, and this product must never be used in humans or animals.
5-Amino-1MQ emerged from medicinal-chemistry efforts to create more potent NNMT inhibitors than the early probe 1-methylquinolinium. Quinoline-derived analogs such as 5-Amino-1MQ showed markedly improved NNMT inhibition, good cell permeability and robust effects on adipocyte methyl-nicotinamide levels, prompting their use in obesity, metabolic syndrome and NAD⁺-related research programs.
5-Amino-1MQ is a quinolinium derivative bearing an amino group at the 5-position and a methyl group on the ring nitrogen. The cation typically has the molecular formula C₁₀H₁₁N₂⁺ with a molecular weight of ~159.2 g/mol (counter-ion dependent). Its planar aromatic scaffold and positive charge support binding in the NNMT nicotinamide site.
In differentiated adipocytes, 5-Amino-1MQ lowers intracellular 1-methylnicotinamide in a concentration-dependent manner, increases NAD⁺ levels and suppresses de novo lipogenesis without significantly inhibiting closely related methyltransferases. In rodent models of diet-induced obesity, NNMT inhibition with 5-Amino-1MQ has been associated with increased energy expenditure, reduced fat mass and improvements in metabolic parameters, supporting NNMT as a target in obesity and cardiometabolic research.
Put simply, 5-Amino-1MQ lets researchers test what happens when cells and animals waste less NAD⁺ and shift fuel use away from fat storage. Early work shows promising shifts in metabolism in lab and animal studies, but these findings are exploratory and not evidence of proven benefits or safety in humans.
Neelakantan H. et al. (2017). Quinoline-derived NNMT inhibitors (including 5-Amino-1MQ) modulate adipocyte NAD⁺ and lipogenesis. Biochemical Journal. PMC +1 Dimet-Wiley A. et al. (2022). NNMT inhibition with 5-Amino-1MQ combined with calorie restriction in obesity models. Scientific Reports. Nature Iyamu I.D. et al. (2021). Mechanisms and inhibitors of NNMT in metabolic disease. Biomolecules. PMC +1 Jawaria S.T. et al. (2025). NNMT as a metabolic regulator and target for small-molecule inhibitors such as 5-Amino-1MQ. Biomolecules.
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These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.
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All compounds from Elite Miami Peptides are intended strictly for laboratory research purposes.
They are not for human use, consumption, or therapeutic applications.
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