Kisspeptin-10 (5mg)

Kisspeptin-10 5mg peptide for sale. A research peptide studied for its role in stimulating GnRH release and supporting reproductive hormone signaling.

Kisspeptin-10 (5mg) For Sale

Source: PubChem

• CAS Number: 374675-21-5

• Molecular Weight: 1302.45 g/mol

• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

• Formula: C₆₃H₈₃N₁₇O₁₄

Kisspeptin-10 is a synthetic decapeptide that corresponds to a fragment of the naturally occurring kisspeptin protein. It plays a crucial role in activating the hypothalamic-pituitary-gonadal (HPG) axis by stimulating the release of gonadotropin-releasing hormone (GnRH). This initial signaling event is essential in the regulation of reproductive function and has made Kisspeptin-10 a widely researched molecule in the fields of reproductive biology and endocrinology.

The kisspeptin family of peptides was originally identified for its tumor-suppressing qualities through its interaction with the KISS1 gene. However, it was later discovered that kisspeptins—particularly Kisspeptin-10—act as upstream regulators of GnRH neurons. Through this mechanism, Kisspeptin-10 indirectly affects the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary, which are both vital for reproductive development and fertility.

Researchers have been especially interested in how Kisspeptin-10 may modulate fertility, influence the timing of puberty, and contribute to our understanding of hormonal signaling. Its specific interaction with the GPR54 receptor (also referred to as KISS1R) has helped shed light on its involvement in both normal and abnormal reproductive states. For example, in animal models, Kisspeptin-10 has been used to mimic or inhibit the onset of puberty, making it useful in studies focused on delayed or precocious puberty.

Current and Emerging Research Areas:

• Fertility Modulation: Kisspeptin-10 has been evaluated for its role in triggering ovulation and stimulating reproductive hormone production, especially in females. In males, it may play a role in regulating testosterone synthesis through the LH pathway.

• Pubertal Onset: As puberty involves a reactivation of the HPG axis, Kisspeptin-10’s role as a GnRH activator is of high interest for understanding and potentially treating disorders related to delayed or early puberty.

• Endocrine Feedback Loops: Researchers continue to study Kisspeptin-10’s role in feedback mechanisms, where sex hormones like estrogen and testosterone influence the HPG axis through kisspeptin signaling pathways.

• Hypogonadism and Hormonal Deficiency Models: In both male and female animal models, Kisspeptin-10 is being studied for its ability to reverse or replicate symptoms of hypogonadism, providing insight into potential therapeutic targets for hormonal deficiencies.

Because of its interaction with the central nervous system and its ability to affect hormonal rhythms, Kisspeptin-10 is also being considered for research into circadian rhythms and metabolic health, although these areas are less developed than its reproductive applications.

Mechanism of Action

Kisspeptin-10 binds with high specificity to the GPR54 (KISS1R) receptor, a G-protein-coupled receptor that is expressed primarily in the hypothalamus. Upon binding, this interaction activates intracellular signaling pathways that stimulate the release of GnRH. The downstream result is a cascade of hormone production that ultimately affects sexual development, reproductive cycles, and fertility outcomes.

Key Details

• Physical Form: Lyophilized powder

• Solubility: Soluble in water

• Purity: ≥98% (by HPLC)

• Storage: Store in a dry, cool environment away from direct sunlight and moisture to maintain peptide stability.

Disclaimer

All products provided by Elite Miami Peptides are strictly intended for laboratory research and in vitro use only. They are not approved or recommended for human ingestion, therapeutic use, or any form of clinical treatment. Kisspeptin-10 is not classified as a drug, dietary supplement, or cosmetic, and no health claims are made regarding its effectiveness or safety in humans. Elite Miami Peptides disclaims all responsibility for the misuse of this research chemical. Browse our entire collection of high quality research peptides for sale in our online peptide shop.